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Sildenafil can be a potent and selective inhibitor of cGMP distinct phosphodiesterase type 5 (PDE5) inside the corpus cavernosum, where by PDE5 is answerable for degradation of cGMP. Sildenafil provides a peripheral web-site of motion on erections. Sildenafil has no direct relaxant impact on isolated human corpus cavernosum but potently enhances th